TRPA

TRPA (Transient Receptor Potential Ankyrin 1) is a protein that in humans is encoded by the TRPA1 gene. It is a member of the Transient Receptor Potential (TRP) channel family, which is a group of ion channels located mostly on the plasma membrane of numerous animal cell types.

Function

TRPA1 is an ion channel found on the plasma membrane of many animal cells, including humans. It is involved in the sensation of pain and cold, and is activated by environmental irritants such as mustard oil, cinnamon oil, and cold temperatures.

TRPA1 is also involved in the inflammatory response. When activated, it allows positively charged ions such as calcium and sodium to flow into the cell, leading to depolarization and the initiation of an action potential. This signal is then transmitted to the brain, resulting in the perception of pain or cold.

Clinical significance

TRPA1 has been implicated in a variety of diseases and conditions, including chronic pain, asthma, and neuropathy. It is a target for the development of new pain medications, and several TRPA1 antagonists are currently in clinical trials.

See also

• Transient Receptor Potential
• Ion channel
• Pain
• Asthma
• Neuropathy

References

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