TRPC1

TRPC1 (Transient Receptor Potential Cation Channel Subfamily C Member 1) is a protein that in humans is encoded by the TRPC1 gene. It is a member of the transient receptor potential channel family, which is a group of ion channels located mostly on the plasma membrane of numerous animal cell types.

Function

TRPC1 is a non-selective cation channel that is considered to be a receptor-operated channel. It is activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and is not activated by intracellular calcium. It is involved in various physiological processes, including neuronal signaling and smooth muscle contraction.

Structure

The TRPC1 protein is composed of six transmembrane domains with a pore loop, a cyclic nucleotide-binding domain, and an ankyrin repeat domain. The protein is part of a complex structure that is also associated with other proteins, such as TRPC4 and TRPC5, forming a heteromultimeric channel complex.

Clinical Significance

Alterations in the function or expression of TRPC1 have been associated with several diseases. For example, it has been implicated in the pathogenesis of hypertension, cardiac hypertrophy, and pulmonary hypertension. Furthermore, TRPC1 has been suggested to play a role in cancer progression, particularly in glioblastoma.

Research

Research on TRPC1 is ongoing, with studies focusing on its role in various physiological and pathological processes. These include its role in cell proliferation, cell death, and cell migration, as well as its potential as a therapeutic target in various diseases.

See Also

• Transient receptor potential channel
• TRPC
• TRPC4
• TRPC5