TRPV3

TRPV3 is a protein that in humans is encoded by the TRPV3 gene. It is a member of the transient receptor potential (TRP) group of ion channels.

Function

TRPV3 is a nonselective cation channel that is considered to be a sensor for warmth in the skin. The channel is activated by warm temperatures and chemical compounds such as camphor and menthol. The protein encoded by this gene is a member of the TRP group of ion channels, which are characterized by a common structural motif, a large number of transmembrane domains, and a C-terminal cytoplasmic domain.

Clinical significance

Mutations in the TRPV3 gene have been associated with Olmsted syndrome, a rare congenital disorder characterized by palmoplantar and periorificial keratoderma, alopecia, and severe pruritus.

Structure

The TRPV3 protein is a homotetramer that forms a cation-selective channel permeable to calcium (Ca2+). The protein is found in the plasma membrane and in intracellular vesicles. It is expressed predominantly in the skin, especially in keratinocytes, the outermost layer of the skin.

Pharmacology

TRPV3 is a target for the development of drugs to treat a variety of conditions, including pain, inflammation, and skin disorders. Several compounds that modulate the activity of TRPV3 have been identified, including natural products, synthetic small molecules, and approved drugs.

See also

• Transient receptor potential channel
• Olmsted syndrome