Tabernanthe iboga

From WikiMD's Food, Medicine & Wellness Encyclopedia

Tabernanthe iboga is a perennial rainforest shrub and psychoactive plant from the Apocynaceae family, native to western Central Africa. It is well known for its root bark, which contains a complex mix of alkaloids, the most notable of which is ibogaine. Ibogaine is used both in traditional spiritual ceremonies of the Bwiti religion in Gabon and as a tool in treating opiate addiction in some Western countries, despite its legality being a contentious issue.

Description[edit | edit source]

Tabernanthe iboga grows to a height of 2 meters and features small green leaves. The flowers are white and pink, while the fruit is a small orange berry containing multiple seeds. The root bark of the plant is rich in alkaloids, primarily ibogaine, which is considered responsible for its psychoactive properties.

Distribution and Habitat[edit | edit source]

Tabernanthe iboga is indigenous to the rainforest regions of Gabon, Cameroon, Congo, and Angola. It thrives in understorey of tropical forests, preferring moist soil conditions.

Uses[edit | edit source]

Traditional[edit | edit source]

In traditional practices, particularly within the Bwiti religion in Gabon, the root bark of Tabernanthe iboga is consumed in small doses for its stimulant effects during hunting. In larger doses, it is used in spiritual initiation ceremonies purported to facilitate profound spiritual visions and insights, believed to be crucial for personal growth and healing.

Medical[edit | edit source]

Ibogaine, the primary alkaloid found in Tabernanthe iboga, has been studied for its potential in treating substance abuse disorders, especially opiate addiction. Small-scale studies and anecdotal reports suggest that ibogaine can significantly reduce withdrawal symptoms and cravings. However, its use is controversial due to its psychoactive effects, potential for cardiac toxicity, and legal status, which varies by country.

Pharmacology[edit | edit source]

Ibogaine affects several neurotransmitter systems simultaneously. It is primarily known for its action on the serotonin transporter and as an NMDA receptor antagonist, which is thought to contribute to its anti-addictive properties. However, the full spectrum of its pharmacological activity is complex and not fully understood.

Legal Status[edit | edit source]

The legal status of Tabernanthe iboga and ibogaine varies significantly from country to country. In some nations, it is classified as a controlled substance, making its possession, sale, and use illegal. In others, it remains unregulated or is legal for use in controlled settings.

Conservation[edit | edit source]

Due to overharvesting and habitat destruction, Tabernanthe iboga is considered at risk. Conservation efforts are necessary to ensure its survival, both for its cultural significance to indigenous practices and potential medicinal uses.

See Also[edit | edit source]

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Contributors: Prab R. Tumpati, MD