Tabernanthine

Tabernanthine is an alkaloid that is found in the Tabernaemontana genus of plants, specifically in the species Tabernaemontana divaricata. It is a member of the iboga alkaloid family, which is known for its psychoactive properties.

Chemical Structure

Tabernanthine is a complex organic compound with the molecular formula C20H24N2O3. It is a tertiary amine and contains a quinoline ring structure. The compound is chiral, meaning it has a non-superimposable mirror image.

Biosynthesis

The biosynthesis of tabernanthine involves the condensation of tryptamine and secologanin to form strictosidine, which is then converted to tabernanthine through a series of enzymatic reactions.

Pharmacology

Tabernanthine has been found to have several pharmacological effects. It has been shown to have antinociceptive properties, meaning it can reduce sensitivity to painful stimuli. It also has antimicrobial activity, and has been found to inhibit the growth of certain bacteria and fungi.

Medical Uses

While tabernanthine is not currently used in mainstream medicine, it has been used in traditional medicine for its analgesic and antimicrobial properties. There is also ongoing research into its potential use in the treatment of addiction.

See Also

• Ibogaine
• Tabernaemontana divaricata
• Alkaloid

Tabernanthine Resources
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