Tabimorelin
Tabimorelin[edit | edit source]
Tabimorelin is a synthetic growth hormone secretagogue that was developed for its potential to stimulate the secretion of growth hormone (GH) in humans. It belongs to a class of compounds known as ghrelin mimetics, which act on the growth hormone secretagogue receptor (GHS-R) to promote the release of growth hormone from the pituitary gland.
Mechanism of Action[edit | edit source]
Tabimorelin functions by binding to the growth hormone secretagogue receptor (GHS-R1a), which is a G-protein coupled receptor located primarily in the pituitary gland and the hypothalamus. Upon binding to this receptor, Tabimorelin mimics the action of the endogenous hormone ghrelin, leading to the activation of intracellular signaling pathways that result in the release of growth hormone into the bloodstream.
Clinical Applications[edit | edit source]
The primary clinical application of Tabimorelin was intended to be the treatment of growth hormone deficiency in adults. By stimulating the release of endogenous growth hormone, Tabimorelin could potentially improve body composition, increase muscle mass, and enhance overall physical performance in individuals with insufficient growth hormone levels.
Development and Research[edit | edit source]
Tabimorelin was developed by Pharmacia and underwent various stages of clinical trials to assess its efficacy and safety. However, despite its promising mechanism of action, the development of Tabimorelin was eventually discontinued. The reasons for discontinuation included suboptimal efficacy in clinical trials and the emergence of side effects that outweighed the potential benefits.
Pharmacokinetics[edit | edit source]
Tabimorelin is administered orally and is absorbed through the gastrointestinal tract. It undergoes hepatic metabolism and is excreted primarily via the kidneys. The pharmacokinetic profile of Tabimorelin includes a relatively short half-life, which necessitates frequent dosing to maintain therapeutic levels of growth hormone stimulation.
Side Effects[edit | edit source]
Common side effects associated with Tabimorelin include nausea, headache, and dizziness. More serious adverse effects can include edema, arthralgia, and hyperglycemia. The risk of side effects was a significant factor in the decision to halt further development of the drug.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
