Talotrexin ammonium
The ammonium salt of an antimetabolite analogue of aminopterin with potential antineoplastic activity.
Mechanism of action of Talotrexin ammonium[edit source]
As a folate antagonist, talotrexin binds to and inhibits the function of dihydrofolate reductase, resulting in the inhibition of folate metabolism, DNA synthesis, and cell division.
Less chance of drug resistance[edit | edit source]
Hydrosoluble, talotrexin is actively transported into cells by the reduced folate carrier (RFC) and, therefore, is unlikely to be associated with P-glycoprotein-mediated multidrug resistance.
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