Tavaborole

Tavaborole is a topical antifungal medication used for the treatment of onychomycosis, a fungal infection that affects the toenails. It is marketed under the brand name Kerydin by Anacor Pharmaceuticals.

Mechanism of Action

Tavaborole works by inhibiting the synthesis of proteins required for fungal growth. It does this by inhibiting the enzyme leucyl-tRNA synthetase, which is necessary for the fungus to make proteins.

Uses

Tavaborole is used for the treatment of onychomycosis of the toenails due to Trichophyton rubrum or Trichophyton mentagrophytes.

Side Effects

The most common side effects of tavaborole include application site reactions, such as redness, irritation, and pain.

Pharmacokinetics

Tavaborole is applied topically and has a half-life of approximately 29.5 hours.

History

Tavaborole was approved by the Food and Drug Administration (FDA) in July 2014.

See Also

• Antifungal medication
• Onychomycosis
• Leucyl-tRNA synthetase

Tavaborole Resources
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