Tavo

Tavo - a dna plasmid that encodes genes for both the p35 and p40 subunits of the heterodimeric human interleukin 12 (hil-12) protein that are separated by an internal ribosome entry site (ires) and under the control of a single cytomegalovirus (cmv) promoter, with potential immunomodulatory and antineoplastic activities. Upon administration via intratumoral injection and electroporation, the plasmid is introduced into human cells resulting in expression and highly-localized secretion of a functional il-12 p70 protein into the tumor microenvironment (tme). Il-12 is a pro-inflammatory cytokine that plays a significant role in priming and maintaining t-helper (th) cells, activating natural killer (nk) cells, and regulating the reactivation and survival of memory t-cells (tm). Increased levels of il-12 in the tme may augment host immune response against tumor cells by inhibiting regulatory t-cells (tregs), t-helper 2 (th2) responses, and myeloid-derived suppressor cells (mdscs). See tavokinogene telseplasmid

‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian