Tedisamil

Tedisamil is a class III antiarrhythmic agent that is used in the treatment of cardiac arrhythmia. It is a non-cardioselective potassium channel blocker that has been shown to have a significant effect on the QT interval in the electrocardiogram.

Etymology[edit | edit source]

The term "Tedisamil" is derived from the chemical name "3,7-bis(dimethylamino)phenothiazin-5-ium chloride".

Tedisamil works by blocking the rapid component of the delayed rectifier potassium current (I_Kr) in the heart. This results in a prolongation of the action potential duration and refractory period, which can help to prevent the occurrence of arrhythmias.

Tedisamil is used in the treatment of various types of cardiac arrhythmias, including atrial fibrillation, atrial flutter, and ventricular tachycardia. It has also been investigated for use in the treatment of angina pectoris and hypertension, although its efficacy in these conditions is less well established.

The most common side effects of Tedisamil include dizziness, nausea, and headache. Less common side effects can include palpitations, chest pain, and shortness of breath. In rare cases, Tedisamil can cause torsades de pointes, a potentially life-threatening type of ventricular tachycardia.

Tedisamil Resources
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