Teglarinad chloride
- teglarinad chloride A water-soluble prodrug of a cyanoguanidine compound with potential antineoplastic activity.
Mechanism of action of Teglarinad chloride[edit source]
In vivo, teglarinad chloride is rapidly converted into active drug through hydrolytic cleavage of a carbonate ester bond. Although the exact mechanism of action has yet to be fully elucidated, the active drug appears to antagonize nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis.
Clinical Trials Using Teglarinad chloride[edit source]
Check for ACTIVE CLINICAL TRIALS
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Contributors: Prab R. Tumpati, MD
