Temelastine

Temelastine.svg

Temelastine is a chemical compound that functions as an antihistamine, specifically targeting the H1 receptor. It is used in the treatment of allergic conditions such as allergic rhinitis and urticaria.

Pharmacology

Temelastine is a selective H1 receptor antagonist, which means it blocks the action of histamine at the H1 receptor sites. Histamine is a chemical that is released during allergic reactions and is responsible for symptoms such as itching, sneezing, and increased mucus production. By blocking these receptors, Temelastine helps alleviate these symptoms.

Chemical Properties

Temelastine has the chemical formula C₁₉H₂₀ClN₃. It is characterized by a piperazine ring, which is a common feature in many antihistamines. The presence of a chlorophenyl group contributes to its activity and selectivity for the H1 receptor.

Clinical Use

Temelastine is primarily used in the management of allergic conditions. It is effective in reducing symptoms associated with:

• Allergic rhinitis - inflammation of the nasal passages due to allergens.
• Urticaria - also known as hives, a condition characterized by itchy welts on the skin.

Side Effects

Like many antihistamines, Temelastine can cause side effects, although they are generally mild. Common side effects include:

• Drowsiness
• Dry mouth
• Dizziness

History and Development

Temelastine was developed as part of a class of second-generation antihistamines, which were designed to minimize the sedative effects seen in first-generation antihistamines. Its development was aimed at providing effective allergy relief with fewer central nervous system side effects.

Also see

• Antihistamine
• Allergic rhinitis
• Urticaria
• H1 receptor antagonist