Temocapril

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Temocapril

Temocapril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure. It is a prodrug which is converted to its active metabolite, temocaprilat, in the liver.

Pharmacology

Temocapril is a prodrug that is metabolized in the liver to produce the active metabolite, temocaprilat. This metabolite inhibits the angiotensin-converting enzyme (ACE), which is involved in the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor and stimulates the release of aldosterone, a hormone that increases sodium and water reabsorption in the kidneys. By inhibiting ACE, temocapril reduces the levels of angiotensin II, leading to decreased vasoconstriction and decreased aldosterone-mediated sodium and water reabsorption. This results in a decrease in blood pressure and a reduction in fluid overload, making temocapril effective in the treatment of hypertension and congestive heart failure.

Clinical Use

Temocapril is used in the treatment of hypertension and congestive heart failure. It may be used alone or in combination with other antihypertensive agents. In patients with congestive heart failure, temocapril is used to reduce symptoms and improve survival.

Side Effects

Common side effects of temocapril include cough, dizziness, headache, fatigue, and rash. Less common but more serious side effects include angioedema, hyperkalemia, and renal impairment. As with all ACE inhibitors, temocapril is contraindicated in pregnancy due to the risk of fetal harm.

See Also

• Angiotensin-converting enzyme inhibitor
• Hypertension
• Congestive heart failure