Tenofovir alafenamide fumarate
Tenofovir alafenamide fumarate (TAF) is an antiretroviral medication used to treat and prevent HIV/AIDS and to treat chronic hepatitis B. It is a prodrug of tenofovir, which means it is metabolized into tenofovir in the body. TAF has a better side effect profile than tenofovir disoproxil fumarate (TDF), another prodrug of tenofovir, particularly in terms of kidney and bone safety.
Pharmacology[edit | edit source]
Tenofovir alafenamide fumarate is a prodrug of tenofovir, an adenosine analogue reverse transcriptase inhibitor. As a prodrug, TAF is metabolized into tenofovir, its active form, in the body. Tenofovir then inhibits the action of reverse transcriptase, an enzyme crucial to the replication of HIV and hepatitis B virus.
Medical uses[edit | edit source]
TAF is used in combination with other antiretroviral medications to treat HIV/AIDS. It is also used to treat chronic hepatitis B when other treatment options are not suitable. TAF is often preferred over TDF due to its improved side effect profile, particularly in terms of kidney and bone safety.
Side effects[edit | edit source]
Common side effects of TAF include nausea, diarrhea, and headache. Serious side effects may include kidney problems, decreased bone density, and a buildup of lactic acid in the blood (lactic acidosis).
History[edit | edit source]
Tenofovir alafenamide fumarate was approved for medical use in the United States in 2015. It is marketed under the brand name Vemlidy by Gilead Sciences.
See also[edit | edit source]
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