Tesaglitazar
Tesaglitazar[edit | edit source]
Tesaglitazar is a pharmaceutical drug that was developed as a dual peroxisome proliferator-activated receptor (PPAR) agonist. It was designed to target both the PPAR-alpha and PPAR-gamma receptors, which are involved in the regulation of lipid metabolism and glucose homeostasis.
Mechanism of Action[edit | edit source]
Tesaglitazar functions by activating the PPAR-alpha and PPAR-gamma receptors. These receptors are nuclear receptors that regulate the expression of genes involved in fatty acid oxidation, lipid metabolism, and insulin sensitivity. By activating these receptors, Tesaglitazar aims to improve insulin resistance and reduce triglyceride levels, which are beneficial effects for patients with type 2 diabetes mellitus and dyslipidemia.
Development and Clinical Trials[edit | edit source]
Tesaglitazar was developed by AstraZeneca and underwent several clinical trials to evaluate its efficacy and safety. The drug showed promise in improving glycemic control and lipid profiles in patients with type 2 diabetes. However, during the clinical trials, concerns arose regarding potential adverse effects, including cardiovascular risk and renal impairment.
Adverse Effects[edit | edit source]
The clinical trials of Tesaglitazar revealed several adverse effects that raised concerns about its safety profile. These included increased risk of edema, weight gain, and potential cardiovascular events. Additionally, there were indications of renal function impairment, which led to further scrutiny of its long-term safety.
Discontinuation[edit | edit source]
Due to the safety concerns identified during the clinical trials, the development of Tesaglitazar was eventually discontinued. The decision was made to halt further development and marketing of the drug, as the risks were deemed to outweigh the potential benefits.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
