Tetratricopeptide repeat domain 16 isoform 1

TTC16 Domains & sites

Tetratricopeptide Repeat Domain 16 Isoform 1 (TTC16 Isoform 1) is a protein that in humans is encoded by the TTC16 gene. This protein belongs to a large family of Tetratricopeptide repeat (TPR) domains containing proteins, which are involved in a variety of cellular processes including protein folding, protein transport, and cell cycle control. The TPR motif is a structural motif consisting of a series of tandem repeats of 34 amino acids, primarily known for mediating protein-protein interactions.

Function

TTC16 Isoform 1, like other proteins with TPR domains, is thought to play a critical role in the assembly and function of multiprotein complexes. The exact function of TTC16 Isoform 1 in human biology is not fully understood, but it is believed to be involved in the regulation of cell division and cellular signaling pathways. Proteins with TPR domains often act as scaffolds to bring together other proteins to form functional complexes, and TTC16 Isoform 1 may serve a similar function.

Gene

The TTC16 gene is located on human chromosome 3. This gene produces multiple mRNA isoforms through alternative splicing, leading to the production of different protein isoforms, including TTC16 Isoform 1. The diversity of isoforms allows for a wide range of functions and regulatory mechanisms at the cellular level.

Clinical Significance

While the specific clinical relevance of TTC16 Isoform 1 has yet to be fully elucidated, proteins with TPR domains have been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Given the role of TPR-containing proteins in critical cellular processes, mutations or dysregulation of the TTC16 gene could potentially contribute to disease pathology. Further research is necessary to understand the potential involvement of TTC16 Isoform 1 in human diseases.

Research Directions

Current research on TTC16 Isoform 1 and other TPR-containing proteins focuses on elucidating their precise roles in cellular processes and disease mechanisms. Understanding the molecular interactions and regulatory networks involving TTC16 Isoform 1 could provide insights into novel therapeutic targets for a range of diseases.

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