Phenindamine

Phenindamine is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is sold under the brand names Nolahist, Phenylhistine, Phenin, and others.

Pharmacology

Phenindamine acts by blocking the effects of histamine in the body. Histamine is a substance that the body produces during an allergic reaction, leading to symptoms such as sneezing, itching, and increased mucus production. By blocking the effects of histamine, phenindamine can relieve these symptoms.

Phenindamine also has anticholinergic effects. This means it can block the action of acetylcholine, a neurotransmitter that is involved in many functions of the body, including muscle movement and the regulation of heart rate and digestion.

Uses

Phenindamine is used to treat symptoms of allergies, including hay fever and urticaria (hives). It can also be used to treat the common cold. By reducing the effects of histamine, it can help to relieve symptoms such as sneezing, itching, runny nose, and watery eyes.

Side Effects

Common side effects of phenindamine include drowsiness, dizziness, dry mouth, blurred vision, constipation, and difficulty urinating. In rare cases, it can cause more serious side effects such as confusion, hallucinations, unusual thoughts or behavior, and severe dizziness or drowsiness.

Interactions

Phenindamine can interact with other medications, including other antihistamines, anticholinergic drugs, and certain antidepressants. It can also interact with alcohol, increasing drowsiness and dizziness.

See Also

• Antihistamine
• Anticholinergic
• Histamine
• Acetylcholine