Thiazovivin

Thiazovivin

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Chemical structure of Thiazovivin

Thiazovivin is a small molecule inhibitor that has been identified as a potent enhancer of stem cell survival and pluripotency. It is primarily used in the field of regenerative medicine and cell biology to improve the efficiency of induced pluripotent stem cell (iPSC) generation and maintenance.

Chemical Properties

Thiazovivin is a member of the class of compounds known as thiazoles, which are characterized by a five-membered ring containing both sulfur and nitrogen atoms. The chemical structure of Thiazovivin includes a thiazole ring, which is crucial for its biological activity.

Mechanism of Action

Thiazovivin functions by inhibiting the activity of Rho-associated protein kinase (ROCK), a kinase involved in the regulation of the cytoskeleton. By inhibiting ROCK, Thiazovivin promotes cell survival and reduces apoptosis, particularly in the context of stem cell cultures. This action is beneficial in maintaining the pluripotency of stem cells and enhancing their ability to proliferate.

Applications in Stem Cell Research

In the field of stem cell research, Thiazovivin is used to:

• Enhance the survival of human embryonic stem cells (hESCs) and iPSCs during the reprogramming process.
• Improve the efficiency of iPSC generation from somatic cells.
• Maintain the pluripotency of stem cells in culture by reducing stress-induced apoptosis.

Advantages and Limitations

The use of Thiazovivin offers several advantages in stem cell research, including increased cell survival rates and improved efficiency of iPSC generation. However, its use is limited by the need for precise dosing and potential off-target effects that may affect other cellular pathways.

Related Pages

• Stem cell
• Induced pluripotent stem cell
• Rho-associated protein kinase
• Thiazole