Thiazovivin

Thiazovivin is a small molecule inhibitor used in cell biology and pharmacology. It is known for its role in enhancing the efficiency of induced pluripotent stem cell (iPSC) generation.

Chemistry

Thiazovivin is a thiazol derivative. It is a synthetic molecule that contains a thiazol ring, which is a five-membered ring with two non-carbon atoms: one nitrogen atom and one sulfur atom.

Mechanism of Action

Thiazovivin acts by inhibiting Rho-associated protein kinase (ROCK), a serine/threonine kinase. ROCK is involved in various cellular functions, including cell adhesion, motility, and proliferation. By inhibiting ROCK, Thiazovivin promotes cell survival and enhances the efficiency of iPSC generation.

Applications

Thiazovivin has been used in various research applications. It is most notably used in the generation of iPSCs. It enhances the efficiency of iPSC generation by promoting cell survival during the reprogramming process. Thiazovivin has also been used in research studying the role of ROCK in various cellular processes and diseases.

Safety and Toxicity

As with any pharmacological agent, Thiazovivin has potential side effects and toxicity. However, these are largely dependent on the dosage and the specific application. It is important to handle Thiazovivin with care and use appropriate safety measures.

See Also

• Rho-associated protein kinase
• Induced pluripotent stem cell
• Cell biology
• Pharmacology