Tiamulin

Tiamulin is a diterpene antibiotic used in veterinary medicine to treat swine diseases such as swine dysentery, pneumonia, and enteritis. It is a member of the pleuromutilin class of antibiotics and acts by inhibiting protein synthesis in bacteria.

History

Tiamulin was first discovered in the 1970s by the Danish company Hoechst. It was initially used to treat swine dysentery, a serious and often fatal disease in pigs. Over time, its use has expanded to include other swine diseases.

Mechanism of action

Tiamulin works by binding to the 50S ribosomal subunit of bacteria, inhibiting protein synthesis. This prevents the bacteria from growing and reproducing, effectively killing them.

Uses

Tiamulin is primarily used in the treatment of swine diseases. It is effective against a variety of bacteria, including Brachyspira hyodysenteriae, the causative agent of swine dysentery, and Actinobacillus pleuropneumoniae, which causes pneumonia in pigs. It is also used to treat enteritis caused by Lawsonia intracellularis.

Side effects

Like all antibiotics, tiamulin can cause side effects. These can include diarrhea, vomiting, and anorexia. In rare cases, it can cause severe neurological side effects, including ataxia and tremors.

Resistance

Resistance to tiamulin has been reported in some bacteria, including Staphylococcus aureus and Enterococcus faecium. This is a concern as it could limit the effectiveness of the drug in the future.

See also

• Pleuromutilin
• Veterinary medicine
• Swine dysentery
• Protein synthesis

Tiamulin Resources
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