Tiapamil

Tiapamil is a calcium channel blocker used in the treatment of cardiovascular disease. It is a non-dihydropyridine member of the phenylalkylamine class, similar to verapamil.

Pharmacology[edit | edit source]

Tiapamil acts by inhibiting the influx of calcium ions into cardiac muscle and smooth muscle cells. This inhibition results in the relaxation of these muscles, leading to a decrease in blood pressure and a reduction in heart rate. It also has anti-arrhythmia properties, making it useful in the treatment of conditions such as atrial fibrillation and supraventricular tachycardia.

Clinical Use[edit | edit source]

Tiapamil is used in the management of hypertension, angina pectoris, and certain types of cardiac arrhythmias. It is also used off-label for the prevention of migraine headaches.

Side Effects[edit | edit source]

Common side effects of Tiapamil include dizziness, fatigue, nausea, and constipation. Less common but more serious side effects can include bradycardia, hypotension, and heart block.

Contraindications[edit | edit source]

Tiapamil is contraindicated in patients with severe heart failure, significant bradycardia, and second- or third-degree heart block without a functioning pacemaker.

Drug Interactions[edit | edit source]

Tiapamil can interact with a number of other medications, including beta blockers, digoxin, and statins. These interactions can lead to increased levels of these medications in the body, potentially resulting in toxicity.