Tipepidine

From WikiMD's Wellness Encyclopedia

Tipepidine (3,3-Diphenylpropylamine) is a synthetic, non-opioid, centrally acting cough suppressant, or antitussive, that has been in use in Japan since 1959. It is most commonly found in the form of a syrup, combined with other ingredients such as Guaifenesin or Pseudoephedrine, to treat symptoms of the common cold.

Pharmacology[edit | edit source]

Tipepidine acts on the central nervous system (CNS) to suppress the cough reflex. While the exact mechanism of action is not fully understood, it is believed to involve modulation of the GABAergic system, similar to other non-opioid antitussives such as Dextromethorphan and Butamirate.

Side Effects[edit | edit source]

Common side effects of Tipepidine include drowsiness, nausea, and dizziness. In rare cases, it can cause hallucinations or other serious mental changes. As with all medications, it should be used under the supervision of a healthcare professional.

Interactions[edit | edit source]

Tipepidine may interact with other CNS depressants, including alcohol, antihistamines, and sedatives, increasing the risk of side effects. It is also known to interact with Monoamine oxidase inhibitors (MAOIs), potentially leading to a hypertensive crisis.

See Also[edit | edit source]

References[edit | edit source]

Tipepidine Resources
Wikipedia
WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD