Tipepidine

Tipepidine (3,3-Diphenylpropylamine) is a synthetic, non-opioid, centrally acting cough suppressant, or antitussive, that has been in use in Japan since 1959. It is most commonly found in the form of a syrup, combined with other ingredients such as Guaifenesin or Pseudoephedrine, to treat symptoms of the common cold.

Pharmacology

Tipepidine acts on the central nervous system (CNS) to suppress the cough reflex. While the exact mechanism of action is not fully understood, it is believed to involve modulation of the GABAergic system, similar to other non-opioid antitussives such as Dextromethorphan and Butamirate.

Side Effects

Common side effects of Tipepidine include drowsiness, nausea, and dizziness. In rare cases, it can cause hallucinations or other serious mental changes. As with all medications, it should be used under the supervision of a healthcare professional.

Interactions

Tipepidine may interact with other CNS depressants, including alcohol, antihistamines, and sedatives, increasing the risk of side effects. It is also known to interact with Monoamine oxidase inhibitors (MAOIs), potentially leading to a hypertensive crisis.

See Also

• Antitussive
• Cough medicine
• Dextromethorphan
• Butamirate

References

Tipepidine Resources
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