Tisopurine

Tisopurine

Tisopurine is a pharmacological agent that belongs to the class of drugs known as purine analogues. It is primarily used in the treatment of various cancer types and autoimmune diseases.

Mechanism of Action

Tisopurine works by inhibiting the synthesis of DNA and RNA, which are essential for cell growth and multiplication. This inhibition is achieved by the drug's ability to mimic the structure of natural purine molecules, which are key components of these genetic materials. By doing so, Tisopurine disrupts the normal functioning of cells, leading to their death.

Medical Uses

Tisopurine is used in the treatment of a variety of cancers, including leukemia, lymphoma, and melanoma. It is also used in the management of autoimmune diseases such as rheumatoid arthritis and psoriasis. The drug is typically administered orally, but can also be given intravenously in certain cases.

Side Effects

Like all drugs, Tisopurine can cause side effects. The most common ones include nausea, vomiting, and diarrhea. More serious side effects can include bone marrow suppression, leading to a decrease in the number of blood cells, and liver toxicity.

Contraindications

Tisopurine is contraindicated in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with severe liver or kidney disease, as these conditions can affect the drug's metabolism and increase the risk of toxicity.

Drug Interactions

Tisopurine can interact with a number of other drugs, including allopurinol, warfarin, and certain antibiotics. These interactions can alter the effectiveness of Tisopurine or increase the risk of side effects.

See Also

• Purine analogue
• Pharmacology
• Cancer
• Autoimmune disease