Tissue-agnostic cancer drug
Tissue-agnostic cancer drugs are antineoplastic drugs that treat cancers based on the mutations that they display, instead of the tissue type in which they appear.[1][2][3] Tissue-agnostic drugs include Pembrolizumab (Keytruda) and Larotrectinib (Vitrakvi).[2] [4]
History[edit | edit source]
Petrolizumab was approved by the US Food and Drug Administration In May 2017.[5]
Larotrectinib was approved by the FDA in November, 2018.[5]
Loxo-292 received priority review in September 2018.[5]
Other drugs under development include Entrectinib, BLU-667, Loxo-195 and Anti-ERBB3 antibody.[5]
References[edit | edit source]
- ↑ Bacon, John, FDA approves new drug reflecting cutting-edge, 'tissue-agnostic' effort to beat cancer Full text, USA Today, 28 November 2018, Accessed on: 3 December 2018.
- ↑ 2.0 2.1 , In a major shift, cancer drugs go 'tissue-agnostic', Science, Vol. 356(Issue: 6343), pp. 1111–1112, DOI: 10.1126/science.356.6343.1111, PMID: 28619894,
- ↑ , Tissue-agnostic cancer drug pipeline grows, despite doubts, Nature, Vol. 17(Issue: 4), pp. 227–229, DOI: 10.1038/nrd.2018.6, PMID: 29520093,
- ↑ Dun, Lauren, FDA approves a new cancer drug targeted to genetic mutation, not cancer type Full text, NBC, 27 Nov 2018, Accessed on: 17 Dec 2018.
- ↑ 5.0 5.1 5.2 5.3 New Gene Targeting Cancer Drugs And Other Advances in Cancer Medicine – NextBigFuture.com Full text, Wang, Brian, www.nextbigfuture.com, June 19, 2019, Accessed on: 2019-06-19.
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