Tissue-selective estrogen complex

Tissue-selective estrogen complex (TSEC) is a type of hormone therapy that combines estrogen with a selective estrogen receptor modulator (SERM). This combination is designed to provide the beneficial effects of estrogen on certain tissues, such as the bones and vagina, while avoiding the negative effects on other tissues, such as the uterus and breasts.

Mechanism of Action

TSECs work by selectively activating estrogen receptors in certain tissues. The estrogen component of the TSEC binds to estrogen receptors throughout the body, while the SERM component selectively blocks the estrogen receptors in tissues where estrogen can have negative effects. This allows for the beneficial effects of estrogen in tissues where it is needed, while minimizing the risk of negative effects in other tissues.

Uses

TSECs are primarily used in the treatment of menopausal symptoms, such as hot flashes and vaginal atrophy. They may also be used in the prevention of osteoporosis in postmenopausal women.

Examples

One example of a TSEC is the combination of conjugated estrogens and bazedoxifene. This combination is marketed under the brand name Duavee in the United States and as Duavive in Europe.

Side Effects

Common side effects of TSECs include nausea, headache, and abdominal pain. More serious side effects can include blood clots, stroke, and endometrial cancer.

See Also

• Hormone therapy
• Selective estrogen receptor modulator
• Menopause
• Osteoporosis

References

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