Tradipitant

Tradipitant is an experimental drug that is being developed by Vanda Pharmaceuticals. It is a neurokinin-1 receptor antagonist that is being studied for its potential use in the treatment of various medical conditions, including gastroparesis, chronic pruritus, and atopic dermatitis.

History

Tradipitant was originally developed by Merck & Co., but the development rights were later acquired by Vanda Pharmaceuticals. The drug is currently in clinical trials to evaluate its safety and efficacy in treating various conditions.

Mechanism of action

Tradipitant works by blocking the neurokinin-1 receptor, which is involved in various physiological processes, including pain perception, stress response, and inflammation. By blocking this receptor, tradipitant may help to alleviate symptoms associated with conditions like gastroparesis, chronic pruritus, and atopic dermatitis.

Clinical trials

Several clinical trials have been conducted to evaluate the safety and efficacy of tradipitant. These trials have shown promising results, but further research is needed to confirm these findings and to determine the optimal dosing regimen for this drug.

Potential uses

Tradipitant is being studied for its potential use in the treatment of various medical conditions, including:

• Gastroparesis: This is a condition in which the muscles in the stomach do not function properly, leading to delayed gastric emptying. Tradipitant may help to alleviate symptoms associated with this condition by blocking the neurokinin-1 receptor.

• Chronic pruritus: This is a condition characterized by persistent itching. Tradipitant may help to alleviate this symptom by blocking the neurokinin-1 receptor.

• Atopic dermatitis: This is a type of inflammation of the skin. Tradipitant may help to alleviate symptoms associated with this condition by blocking the neurokinin-1 receptor.

See also

• Neurokinin-1 receptor antagonist
• Vanda Pharmaceuticals
• Clinical trial

Tradipitant Resources
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