Trafficking protein particle complex 11
Trafficking protein particle complex 11 (TRAPPC11) is a protein that in humans is encoded by the TRAPPC11 gene. The protein encoded by this gene is part of a large protein complex, which is involved in the vesicular transport of proteins to various cellular compartments.
Function[edit | edit source]
The TRAPPC11 protein is a component of the TRAPP protein complex. This complex functions in vesicle transport, a process that moves molecules between different compartments within the cell. Specifically, the TRAPP complex is involved in the transport of proteins from the endoplasmic reticulum, where they are made, to the Golgi apparatus, where they are modified and sorted for transport to their final destinations.
Clinical significance[edit | edit source]
Mutations in the TRAPPC11 gene have been associated with several diseases. These include limb-girdle muscular dystrophy type 2S (LGMD2S), a form of muscular dystrophy characterized by progressive muscle weakness and wasting, and myopathy with extrapyramidal signs, a condition characterized by muscle weakness and movement problems.
See also[edit | edit source]
References[edit | edit source]
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