Transferrin saturation
Transferrin Saturation[edit | edit source]
Transferrin saturation is a clinical measure used to evaluate the proportion of iron bound to transferrin in the blood. Transferrin is a protein that plays a crucial role in transporting iron throughout the body. Understanding transferrin saturation levels is important in diagnosing and managing various iron-related disorders.
Overview[edit | edit source]
Transferrin saturation is calculated by comparing the level of serum iron (iron circulating in the blood) to the total iron-binding capacity (TIBC) of transferrin. It is usually expressed as a percentage.
Importance of Iron Transport[edit | edit source]
- Iron is an essential element for various bodily functions, particularly for the formation of hemoglobin in red blood cells.
- Transferrin acts as the primary carrier of iron in the blood, delivering it to where it is needed in the body.
Calculation of Transferrin Saturation[edit | edit source]
Transferrin saturation is calculated using the formula: \[ \text{Transferrin Saturation (\%)} = \left( \frac{\text{Serum Iron}}{\text{TIBC}} \right) \times 100 \]
- Serum Iron: The amount of iron in the blood.
- TIBC: Total iron-binding capacity, indicating the maximum amount of iron that transferrin can transport.
Clinical Significance[edit | edit source]
Transferrin saturation is an important parameter in diagnosing and managing iron metabolism disorders, such as:
- Iron Deficiency Anemia: Characterized by low transferrin saturation.
- Hemochromatosis: A condition leading to iron overload, often indicated by high transferrin saturation levels.
Normal Ranges[edit | edit source]
The normal range for transferrin saturation typically falls between 20% and 50%. Values outside this range may indicate an imbalance in iron metabolism.
External Links[edit | edit source]
Transferrin saturation Resources | ||
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