Transfusion-dependent anemia
A condition requiring regular blood transfusions
Transfusion-dependent anemia is a type of anemia that necessitates regular blood transfusions to manage the condition. This form of anemia is often associated with chronic diseases or genetic disorders that impair the body's ability to produce healthy red blood cells.
Causes[edit | edit source]
Transfusion-dependent anemia can result from various underlying conditions, including:
- Thalassemia: A genetic disorder that affects hemoglobin production.
- Sickle cell disease: A hereditary disease that causes red blood cells to become misshapen and break down.
- Myelodysplastic syndromes: A group of disorders caused by poorly formed or dysfunctional blood cells.
- Aplastic anemia: A condition where the bone marrow fails to produce sufficient blood cells.
Management[edit | edit source]
The primary treatment for transfusion-dependent anemia is regular blood transfusions. These transfusions help maintain adequate hemoglobin levels and alleviate symptoms such as fatigue and weakness. However, frequent transfusions can lead to iron overload, necessitating additional treatments.
Iron Chelation Therapy[edit | edit source]
To manage iron overload, patients may require iron chelation therapy. Common chelating agents include:
- Deferoxamine: Administered via injection, it binds to excess iron, allowing it to be excreted from the body.
- Deferiprone: An oral medication that also binds to iron, facilitating its removal.
Complications[edit | edit source]
Patients with transfusion-dependent anemia are at risk of several complications, including:
- Iron overload: Excess iron from repeated transfusions can damage organs such as the heart and liver.
- Infections: Increased risk due to frequent blood transfusions.
- Alloimmunization: Development of antibodies against transfused blood cells, complicating future transfusions.
Prognosis[edit | edit source]
The prognosis for individuals with transfusion-dependent anemia varies depending on the underlying cause and the effectiveness of treatment. With proper management, many patients can maintain a good quality of life.
Related pages[edit | edit source]
References[edit | edit source]
Blood bag sample
Deferoxamine 3D model
Deferiprone Iron complex
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