Translational Research

Translational Research is a type of research that aims to improve the health of individuals by "translating" findings in fundamental research into medical practice and meaningful health outcomes. Translational research involves the application of discoveries generated during research in the laboratory, and in preclinical studies, to the development of trials and studies in humans.

Overview

Translational research, often referred to as "bench-to-bedside" research, is characterized by collaborations between many different disciplines, including biology, chemistry, medicine, public health, and others. The goal of these collaborations is to apply knowledge from basic sciences to enhance human health and well-being.

Translational research is a critical component of the National Institutes of Health's strategy to improve the health of the nation. It is also a key aspect of the work of many other health organizations worldwide.

Stages of Translational Research

Translational research typically involves two stages: T1 and T2.

T1 research (also known as "bench-to-bedside" research) involves applying discoveries from laboratory research to the development of clinical trials and studies in humans.

T2 research (also known as "bedside-to-community" research) involves enhancing the adoption of best practices in the community.

Challenges

Despite its potential, translational research faces several challenges. These include the "valley of death" (a gap between basic research and clinical application), regulatory hurdles, and difficulties in coordinating multidisciplinary teams.

See Also

• Clinical Research
• Medical Research
• Public Health

References

Translational Research Resources
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