Trapidil
Trapidil is a vasodilator and platelet aggregation inhibitor that is used in the treatment of vascular disease. It is a derivative of pyrimido-pyrimidine, and it works by inhibiting the release of growth factors from platelets, which in turn inhibits smooth muscle growth. This makes it useful in the treatment of conditions such as atherosclerosis and restenosis.
Mechanism of Action[edit | edit source]
Trapidil acts as an antagonist of the platelet-derived growth factor (PDGF) receptor. PDGF is a potent stimulator of growth for vascular smooth muscle cells, and its inhibition by Trapidil helps to prevent the proliferation of these cells, which is a key factor in the development of atherosclerosis and restenosis.
Clinical Uses[edit | edit source]
Trapidil is used in the treatment of various vascular diseases, including atherosclerosis and restenosis. It is also used in the prevention of coronary artery disease, and in the treatment of pulmonary hypertension.
Side Effects[edit | edit source]
Like all medications, Trapidil can cause side effects. These can include nausea, vomiting, diarrhea, and abdominal pain. In rare cases, it can cause serious side effects such as liver damage or bleeding.
Contraindications[edit | edit source]
Trapidil should not be used in patients with known hypersensitivity to the drug. It should also be used with caution in patients with liver disease or bleeding disorders.
See Also[edit | edit source]
Trapidil Resources | ||
---|---|---|
|
|
Translate to: East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD