Treosulfan

Treosulfan.svg

Treosulfan is a chemotherapy agent used primarily in the treatment of ovarian cancer. It is an alkylating agent that works by interfering with the DNA replication process in cancer cells, leading to cell death. Treosulfan is also being investigated for its potential use in hematopoietic stem cell transplantation (HSCT).

Mechanism of Action[edit | edit source]

Treosulfan is a prodrug that is converted in the body to a bifunctional alkylating agent. It forms cross-links in DNA, which prevents the cancer cells from dividing and leads to apoptosis. This mechanism is similar to other alkylating agents like cyclophosphamide and melphalan.

Clinical Uses[edit | edit source]

Treosulfan is primarily used in the treatment of ovarian cancer, particularly in patients who have not responded to other treatments. It is also being studied for use in hematopoietic stem cell transplantation as a conditioning agent. This involves preparing the patient's body to receive new stem cells by eliminating existing bone marrow cells.

Administration and Dosage[edit | edit source]

Treosulfan is usually administered intravenously. The dosage and schedule depend on the type and stage of cancer being treated, as well as the patient's overall health and response to the medication. It is often given in combination with other chemotherapy drugs.

Side Effects[edit | edit source]

Common side effects of treosulfan include:

Nausea
Vomiting
Myelosuppression (decreased production of blood cells)
Alopecia (hair loss)
Fatigue

More severe side effects can include:

Infections due to low white blood cell counts
Bleeding due to low platelet counts
Anemia due to low red blood cell counts

Research and Development[edit | edit source]

Treosulfan is currently being studied in various clinical trials to evaluate its efficacy and safety in different types of cancer and in hematopoietic stem cell transplantation. Researchers are also investigating its potential use in combination with other chemotherapy agents and targeted therapies.

References[edit | edit source]

External Links[edit | edit source]

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