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Tissue factor, also known as TF, factor III, or CD142, is a protein encoded by the F3 gene in humans. It is a cell surface glycoprotein that initiates the extrinsic pathway of blood coagulation in response to tissue damage.
Function[edit | edit source]
Tissue factor is a transmembrane protein and is a member of the cytokine receptor superfamily. This protein is the primary initiator of the blood coagulation cascade after injury. Its function is to bind and activate the plasma serine protease, factor VII and factor VIIa, to initiate the coagulation pathway.
Clinical significance[edit | edit source]
Tissue factor is important in our understanding of the mechanisms of thrombosis, inflammation, and cancer biology. It is associated with an increased risk of thrombosis in diseases such as cancer, atherosclerosis, and septicemia. Its role in the development of these diseases is currently being studied.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
