Tricaine

Tricaine also known as MS-222 or Ethyl 3-aminobenzoate methanesulfonate is a local anesthetic used in veterinary practice for the sedation, anesthesia, and direct euthanasia of fish and other cold-blooded animals.

Chemistry

Tricaine is a white crystalline powder that is soluble in water. Its chemical formula is C9H11NO2·CH4O3S and its molecular weight is 261.30 g/mol. The compound is a derivative of benzoic acid and ethanolamine.

Pharmacology

Tricaine acts by blocking sodium channels on the nerve membrane, preventing the propagation of nerve impulses and thus causing anesthesia. The drug is rapidly metabolized by the liver and excreted in the urine.

Uses

Tricaine is primarily used in the veterinary field, especially in the treatment of fish and other cold-blooded animals. It is used for sedation, anesthesia, and euthanasia. It is also used in scientific research for the immobilization of fish to allow for procedures such as tagging or surgery.

Side Effects

Possible side effects of tricaine include decreased heart rate, decreased respiratory rate, and decreased blood pressure. Overdose can lead to respiratory arrest and death.

See Also

• Anesthesia
• Veterinary medicine
• Sodium channels