Tricaine mesylate

Tricaine mesylate (also known as MS-222, TMS, or Ethyl 3-aminobenzoate methanesulfonate) is a local anesthetic commonly used in veterinary medicine. It is primarily used for the anesthesia, sedation, and euthanasia of fish and amphibians.

Chemical Structure

Tricaine mesylate is a white crystalline powder with the chemical formula C9H11NO2·CH4O3S. It is soluble in water and has a pKa of 2.5. The compound is a derivative of benzoic acid and ethanolamine, and its structure includes an amine group and a benzene ring.

Pharmacology

Tricaine mesylate acts as a sodium channel blocker, inhibiting the propagation of action potentials in nerve and muscle cells. This results in a loss of sensation, providing effective anesthesia. The drug is rapidly metabolized by the liver, and its effects are reversible upon discontinuation.

Usage

In veterinary medicine, tricaine mesylate is used for the anesthesia of fish and amphibians. It is the only anesthetic approved by the Food and Drug Administration (FDA) for use in fish. The drug is also used for the euthanasia of small fish.

Side Effects

Potential side effects of tricaine mesylate include respiratory depression, cardiac arrhythmias, and death at high doses. It is important to monitor the animal's vital signs during use and to adjust the dosage as necessary.

See Also

• Local anesthetic
• Veterinary medicine
• Sodium channel blocker
• Food and Drug Administration