Tricaprylin

Tricaprylin
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CAS Number	538-23-8
PubChem	8907
DrugBank	DB13945
ChemSpider	8560
KEGG	D07273

Tricaprylin is a triglyceride that is composed of three caprylic acid molecules esterified to a glycerol backbone. It is a medium-chain triglyceride (MCT) that is used in various medical and nutritional applications.

Medical Uses

Tricaprylin is used in the treatment of certain medical conditions, particularly those involving fat malabsorption and epilepsy. It is often included in ketogenic diets, which are high-fat, low-carbohydrate diets used to manage epilepsy, especially in children who do not respond to conventional anticonvulsant medications.

Mechanism of Action

As a medium-chain triglyceride, tricaprylin is metabolized differently from long-chain triglycerides. It is absorbed directly into the portal vein and transported to the liver, where it is rapidly oxidized to ketone bodies. These ketone bodies can be used as an alternative energy source by the brain and other tissues, which is beneficial in conditions like epilepsy.

Nutritional Uses

Tricaprylin is also used as a nutritional supplement. It provides a source of calories that is easily absorbed and metabolized, making it useful for individuals with digestive disorders that impair fat absorption. It is also used in sports nutrition to provide a quick source of energy.

Safety and Side Effects

Tricaprylin is generally considered safe when used as directed. However, excessive consumption can lead to gastrointestinal discomfort, including diarrhea, nausea, and abdominal cramping. It is important to use tricaprylin under the guidance of a healthcare professional, especially in therapeutic contexts.

See Also

• Medium-chain triglyceride
• Ketogenic diet
• Caprylic acid

External Links

• DrugBank: Tricaprylin
• PubChem: Tricaprylin