Trichomonasvirus

Trichomonasvirus is a genus of viruses in the family Totiviridae. The viruses in this genus infect protozoa, specifically the species Trichomonas vaginalis. Trichomonasvirus is notable for its role in the pathogenesis of trichomoniasis, a common sexually transmitted infection.

Structure

Trichomonasviruses are non-enveloped, with icosahedral geometries, and T=2 symmetry. The diameter is around 33 nm. Genomes are linear, around 4.6-6.3 kb in length. The genome codes for 2 proteins.

Life Cycle

Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral proteins to host receptors, which mediates endocytosis. Replication follows the double-stranded RNA virus replication model. Double-stranded RNA virus transcription is the method of transcription. The virus exits the host cell by monopartite non-tubule guided viral movement. Protozoa serve as the natural host.

Clinical Significance

The presence of Trichomonasvirus may influence the pathogenicity of Trichomonas vaginalis, the protozoan responsible for trichomoniasis. Some studies suggest that the virus may enhance the virulence of T. vaginalis, leading to more severe symptoms in infected individuals.

See Also

• Trichomoniasis
• Totiviridae
• Trichomonas vaginalis