Tricyclic

Tricyclic refers to a class of drugs primarily used as antidepressants. Tricyclic antidepressants (TCAs) were among the first antidepressants developed and were first introduced in the 1950s. They are named after their chemical structure, which contains three rings of atoms.

History

The first TCA, imipramine, was discovered in the early 1950s. It was initially intended to treat schizophrenia, but was found to have significant antidepressant effects. This led to the development of other TCAs.

Mechanism of action

TCAs work by inhibiting the reuptake of certain neurotransmitters, such as serotonin and norepinephrine, thereby increasing their levels in the brain. This is believed to help alleviate the symptoms of depression.

Uses

While TCAs are primarily used to treat depression, they are also used for other conditions such as chronic pain, anxiety disorders, and certain types of neuropathy.

Side effects

Common side effects of TCAs include dry mouth, blurred vision, constipation, urinary retention, and dizziness. More serious side effects can include cardiac arrhythmia, seizures, and an increased risk of suicide.

See also

• Selective serotonin reuptake inhibitors
• Monoamine oxidase inhibitors
• Atypical antidepressants

References

Tricyclic Resources
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