Trientine hydrochloride

Trientine hydrochloride is a chelating agent used primarily in the treatment of Wilson's disease, a genetic disorder that leads to excessive accumulation of copper in the body. It is an alternative to penicillamine, another chelating agent, for patients who are intolerant to penicillamine.

Mechanism of Action

Trientine hydrochloride works by binding to copper ions in the body, forming a stable complex that can be excreted in the urine. This helps to reduce the levels of copper in tissues and organs, thereby alleviating the symptoms and preventing the progression of Wilson's disease.

Indications

Trientine hydrochloride is indicated for:

• Treatment of Wilson's disease in patients who are intolerant to penicillamine.
• Maintenance therapy for patients who have been initially treated with penicillamine or other chelating agents.

Dosage and Administration

The dosage of trientine hydrochloride varies depending on the severity of the condition and the patient's response to treatment. It is usually administered orally, and the dosage is adjusted based on regular monitoring of copper levels in the body.

Side Effects

Common side effects of trientine hydrochloride include:

• Gastrointestinal disturbances such as nausea and vomiting
• Allergic reactions like rash and itching
• Hematological abnormalities such as anemia

Precautions

Patients taking trientine hydrochloride should be monitored regularly for copper levels, liver function, and potential side effects. It is also important to avoid taking iron supplements concurrently, as iron can interfere with the absorption of trientine.

Related Pages

• Wilson's disease
• Copper
• Penicillamine
• Chelation therapy