Trientine tetrahydrochloride

Trientine Tetrahydrochloride is a chelating agent specifically designed to bind and expel excess copper from the body. This compound is primarily used in the treatment of Wilson's disease, a rare inherited disorder that causes copper to accumulate in the body's vital organs.

Chemistry

Trientine Tetrahydrochloride, also known as Trien, is a white to off-white crystalline powder with the chemical formula C6H18N4•4HCl. It is soluble in water and has a molecular weight of 219.66 g/mol. The compound is a strong chelator, meaning it has the ability to bind to metal ions, in this case, copper.

Pharmacology

Trientine works by removing the excess copper in the body. It does this by binding to the copper and forming a stable complex, which is then excreted from the body through the urine. This reduces the levels of copper in the body, helping to alleviate the symptoms of Wilson's disease.

Clinical Use

Trientine Tetrahydrochloride is used as a second-line treatment for patients with Wilson's disease who are intolerant to the first-line treatment, D-penicillamine. It may also be used in cases where D-penicillamine is not effective. The drug is taken orally, usually two to four times a day.

Side Effects

Like all medications, Trientine Tetrahydrochloride can cause side effects. Common side effects include nausea, vomiting, diarrhea, and abdominal pain. In rare cases, it can cause more serious side effects such as anemia, leukopenia, and thrombocytopenia.

See Also

• Wilson's disease
• Chelation therapy
• D-penicillamine