Triamcinolone acetonide
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Synthetic corticosteroid used to treat various skin conditions
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Triamcinolone acetonide is a synthetic corticosteroid used to treat various skin conditions, reduce inflammation, and suppress the immune system. It is commonly marketed under brand names such as Kenalog and Nasacort.
Medical uses[edit | edit source]
Triamcinolone acetonide is used in the treatment of various dermatological conditions, including eczema, psoriasis, and allergic reactions. It is also used in the management of rheumatoid arthritis and systemic lupus erythematosus. The drug can be administered topically, intramuscularly, intralesionally, or via inhalation.
Topical use[edit | edit source]
When applied topically, triamcinolone acetonide helps to reduce inflammation and alleviate symptoms associated with skin conditions such as eczema and psoriasis. It is available in various forms, including creams, ointments, and lotions.
Intramuscular and intralesional use[edit | edit source]
Triamcinolone acetonide can be injected directly into muscles or lesions to treat conditions like rheumatoid arthritis and keloids. This method of administration helps to deliver the medication directly to the affected area, providing targeted relief.
Inhalation[edit | edit source]
Inhaled triamcinolone acetonide is used to manage respiratory conditions such as asthma and allergic rhinitis. It helps to reduce inflammation in the airways, making it easier to breathe.
Side effects[edit | edit source]
Common side effects of triamcinolone acetonide include skin irritation, dryness, and burning sensation at the application site. Systemic side effects may include weight gain, mood changes, and increased blood pressure. Long-term use can lead to more serious side effects such as osteoporosis, cataracts, and adrenal suppression.
Mechanism of action[edit | edit source]
Triamcinolone acetonide works by binding to glucocorticoid receptors, which leads to the suppression of inflammatory responses and modulation of the immune system. This action helps to reduce the symptoms associated with inflammatory and autoimmune conditions.
Pharmacokinetics[edit | edit source]
Triamcinolone acetonide is metabolized in the liver and has an elimination half-life of approximately 88 minutes. It is excreted primarily through the kidneys.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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