Trifluoroethanol

Trifluoroethanol is a type of organic compound that is classified as an alcohol. It is a colorless, volatile liquid that is used in a variety of applications, including as a solvent in organic chemistry and as a precursor to some pharmaceuticals.

Structure and Properties

Trifluoroethanol has the chemical formula C2H3F3O. It is a structural isomer of 1,1,1,2-tetrafluoroethane, and is characterized by its three fluorine atoms and one hydroxyl group. The presence of the fluorine atoms gives trifluoroethanol its unique properties, including its high polarity and ability to act as a hydrogen bond donor.

Synthesis

Trifluoroethanol can be synthesized through several methods. One common method is the oxidation of 1,1,1-trifluoro-2-iodoethane with potassium hydroxide. Another method is the reaction of hexafluoropropene with steam in the presence of a catalyst.

Applications

Trifluoroethanol is used in a variety of applications. In organic chemistry, it is used as a solvent due to its high polarity and ability to stabilize positive charges. It is also used as a precursor to some pharmaceuticals, including fluoxetine and paroxetine. In addition, trifluoroethanol is used in the production of fluoropolymers.

Safety

Trifluoroethanol is a volatile liquid and should be handled with care. It can cause irritation to the skin and eyes, and prolonged exposure can lead to serious health effects. Proper safety measures should be taken when handling trifluoroethanol, including the use of protective clothing and adequate ventilation.

See Also

• Fluorinated compound
• Organofluorine chemistry
• Fluoropolymers

References

Trifluoroethanol Resources
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