Trimeperidine

Trimeperidine

Trimeperidine is a synthetic opioid analgesic drug, first synthesized in the Soviet Union in the 1950s. It is chemically related to pethidine (meperidine) and is used in much the same way as morphine for the relief of moderate to severe pain.

Chemistry

Trimeperidine, also known as promedol, is a 4-phenylpiperidine derivative that is structurally related to the opioid analgesic, pethidine. The chemical name for trimeperidine is 1,2,5-Trimethyl-4-phenyl-4-propionoxypiperidine.

Pharmacology

Trimeperidine's analgesic and antispasmodic properties are due to its action on the central nervous system and the smooth muscle tissues. It is believed to act on the mu-opioid receptor, although it may also have effects on other opioid receptors. Trimeperidine has a rapid onset of action and a short duration of effect, which makes it useful for the relief of acute pain.

Medical uses

Trimeperidine is used for the relief of moderate to severe pain, including post-operative pain, trauma pain, and pain associated with cancer. It is also used for its antispasmodic effects in the treatment of certain types of colic, including renal colic and biliary colic.

Side effects

Like other opioids, trimeperidine can cause a range of side effects, including nausea, vomiting, constipation, and drowsiness. It can also cause respiratory depression, which can be life-threatening if not treated promptly. Other potential side effects include confusion, hallucinations, and dependence.

See also

• Opioid
• Pethidine
• Morphine