Triptorelin pamoate

Triptorelin pamoate is a synthetic decapeptide agonist analog of gonadotropin-releasing hormone (GnRH). It is used as a gonadotropin-releasing hormone agonist (GnRH agonist) in the treatment of hormone-responsive cancers such as prostate cancer and breast cancer, as well as in the management of endometriosis and uterine fibroids. Triptorelin pamoate is also utilized in assisted reproduction to control ovarian stimulation.

Mechanism of Action

Triptorelin pamoate works by initially stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland. This initial surge is followed by a downregulation of GnRH receptors, leading to a significant decrease in LH and FSH levels. The reduction in these hormones results in decreased production of testosterone in males and estrogen in females, which is beneficial in treating hormone-sensitive conditions.

Medical Uses

Prostate Cancer

Triptorelin pamoate is used in the treatment of advanced prostate cancer by reducing testosterone levels, which can slow the growth of cancer cells.

Breast Cancer

In premenopausal women with hormone-sensitive breast cancer, triptorelin pamoate helps to lower estrogen levels, thereby inhibiting the growth of cancer cells.

Endometriosis

Triptorelin pamoate is effective in managing endometriosis by reducing estrogen levels, which can alleviate symptoms such as pelvic pain and menstrual irregularities.

Uterine Fibroids

The drug is also used to shrink uterine fibroids by lowering estrogen levels, which can reduce symptoms like heavy menstrual bleeding and pelvic pressure.

Assisted Reproduction

In assisted reproductive technology (ART), triptorelin pamoate is used to control ovarian stimulation, preventing premature ovulation and improving the chances of successful in vitro fertilization (IVF).

Side Effects

Common side effects of triptorelin pamoate include hot flashes, headache, mood changes, and injection site reactions. Long-term use may lead to decreased bone density, so monitoring and preventive measures are recommended.

Administration

Triptorelin pamoate is administered via intramuscular injection. The dosing schedule varies depending on the condition being treated and the specific formulation used.

Related Pages

• Gonadotropin-releasing hormone
• Prostate cancer
• Breast cancer
• Endometriosis
• Uterine fibroids
• Assisted reproductive technology
• In vitro fertilization