Tropine
Tropine is an organic compound and a tertiary amine, which is used as a building block in the preparation of a variety of pharmaceuticals. It is a derivative of tropane containing a nitrogen atom. Tropine is a bicyclic molecule, with one of the cycles being a piperidine.
Structure and reactivity[edit | edit source]
Tropine is a bicyclic molecule, with one of the cycles being a piperidine. The other cycle is a cycloheptane structure. The nitrogen atom in the piperidine ring makes tropine a tertiary amine. The molecule is chiral, with the nitrogen atom being a stereocenter.
Synthesis[edit | edit source]
Tropine can be synthesized from tropane through a series of chemical reactions. The first step is the reduction of the nitrogen atom in tropane to form a secondary amine. This is followed by a Mannich reaction, which introduces a new carbon atom to the molecule. The final step is a reduction of the newly formed imine to a tertiary amine, resulting in tropine.
Uses[edit | edit source]
Tropine is used as a building block in the synthesis of a variety of pharmaceuticals. It is a key intermediate in the production of atropine, a drug used to treat certain types of heart disease, and scopolamine, a drug used to treat motion sickness and postoperative nausea and vomiting.
See also[edit | edit source]
References[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD