U-32,802A

Chemical compound

U-32,802A
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U-32,802A is a chemical compound that acts as a potent and selective dopamine reuptake inhibitor. It is primarily used in scientific research to study the dopaminergic system and its role in various neurological and psychiatric disorders.

Chemical Structure and Properties

U-32,802A is classified as a piperidine derivative. The chemical structure consists of a piperidine ring substituted with a 3-hydroxyphenyl group and an N-propyl group. This configuration is crucial for its activity as a dopamine reuptake inhibitor.

Structural formula of U-32,802A

The molecular formula of U-32,802A is C₁₄H₂₁NO, and it has a molecular weight of 219.32 g/mol. The presence of the hydroxyphenyl group contributes to its ability to interact with the dopamine transporter, inhibiting the reuptake of dopamine into presynaptic neurons.

Pharmacology

U-32,802A functions by selectively inhibiting the dopamine transporter (DAT), which increases the concentration of dopamine in the synaptic cleft. This action enhances dopaminergic neurotransmission, which is a mechanism shared by several psychostimulant drugs.

The selectivity of U-32,802A for the dopamine transporter over other monoamine transporters, such as the serotonin transporter (SERT) and the norepinephrine transporter (NET), makes it a valuable tool in research. It allows scientists to study the specific effects of increased dopaminergic activity without the confounding effects of other neurotransmitter systems.

Research Applications

U-32,802A is used in various research settings to explore the role of dopamine in the brain. It is particularly useful in studies investigating the pathophysiology of disorders such as Parkinson's disease, schizophrenia, and attention deficit hyperactivity disorder (ADHD).

In animal models, U-32,802A is employed to simulate conditions of increased dopaminergic activity, providing insights into the behavioral and neurochemical changes associated with such states. This research contributes to the development of new therapeutic strategies for managing disorders involving dopaminergic dysregulation.

Safety and Handling

As with many research chemicals, U-32,802A should be handled with care in a controlled laboratory environment. Appropriate safety measures, including the use of personal protective equipment (PPE) and adherence to safety protocols, are essential to prevent exposure and ensure safe handling.

Related Pages

• Dopamine reuptake inhibitor
• Dopaminergic system
• Piperidine
• Neurotransmitter