U0126

U0126

U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase. U0126 functions as a highly potent, selective and cell-permeable inhibitor of MEK1 and MEK2. It is often used in cellular biology to understand cell signaling, including apoptosis, proliferation and differentiation.

Mechanism of Action

U0126 inhibits MEK1 and MEK2 by binding to the inactive forms of each enzyme, preventing their activation by upstream kinases. This inhibition prevents the phosphorylation of ERK1/2, thus blocking the activation of the MAPK/ERK pathway. This pathway is involved in the regulation of various cellular processes, including cell growth, differentiation, and survival.

Applications

U0126 has been used in a variety of research applications. It is often used in studies of cell signaling to inhibit the MAPK/ERK pathway. This can help researchers understand the role of this pathway in various cellular processes, such as cell growth and apoptosis. U0126 has also been used in studies of cancer, as the MAPK/ERK pathway is often dysregulated in cancer cells.

Safety and Toxicity

As with any chemical, safety precautions should be taken when handling U0126. It is recommended to avoid contact with skin and eyes, and to use in a well-ventilated area. The toxicity of U0126 is not fully understood, and it is recommended to handle with care.

See Also

• MEK1
• MEK2
• MAPK/ERK pathway
• ERK1/2
• Apoptosis
• Cell signaling