UGT2B7

Human gene encoding an enzyme involved in glucuronidation

UGT2B7 is a gene in humans that encodes the enzyme UDP-glucuronosyltransferase 2B7. This enzyme is part of the glucuronidation pathway, which is a major phase II metabolic pathway that facilitates the elimination of lipophilic xenobiotics and endogenous compounds.

Function

UGT2B7 is involved in the glucuronidation of a wide variety of substrates, including steroid hormones, bile acids, and drugs. The enzyme catalyzes the transfer of glucuronic acid from uridine diphosphate glucuronic acid (UDPGA) to these substrates, making them more water-soluble and easier to excrete from the body.

Structure

The UGT2B7 enzyme contains several important structural features, including the Rossmann fold, which is crucial for its function. The Rossmann fold is a common motif in proteins that bind nucleotides, such as NAD(P)H or FAD.

Diagram of the Rossmann folds in UGT2B7.

Genetic Variability

The UGT2B7 gene exhibits genetic polymorphisms that can affect enzyme activity. One notable polymorphism is the C802T variant, which has been studied for its impact on drug metabolism and efficacy.

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Effects of the C802T polymorphism on UGT2B7 activity.

Clinical Significance

Variations in UGT2B7 activity due to genetic polymorphisms can influence the pharmacokinetics of drugs metabolized by this enzyme. This has implications for drug dosing and efficacy, as well as the risk of adverse drug reactions. UGT2B7 is also involved in the metabolism of endogenous compounds, and its activity can affect physiological processes such as hormone regulation.

Related pages

• Glucuronidation
• UDP-glucuronosyltransferase
• Phase II metabolism