Glucuronidation

Glucuronidation is a biochemical process that involves the addition of a glucuronic acid molecule to a substrate. This process is part of the Phase II metabolism in the liver, which is responsible for the detoxification of various substances.

Process

Glucuronidation is catalyzed by the enzyme UDP-glucuronosyltransferase (UGT). The UGT enzyme transfers a glucuronic acid molecule from uridine diphosphate glucuronic acid (UDPGA) to the substrate. This process increases the solubility of the substrate, making it easier for the body to excrete it.

Role in Drug Metabolism

Glucuronidation plays a crucial role in the metabolism of many drugs and xenobiotics. By increasing the solubility of these substances, glucuronidation facilitates their excretion from the body. This process is particularly important for drugs that are not easily excreted by the kidneys.

Clinical Significance

Alterations in glucuronidation can have significant clinical implications. For example, individuals with Gilbert's syndrome have a reduced capacity for glucuronidation, which can lead to an increased risk of drug toxicity. Additionally, certain drugs can inhibit or induce the UGT enzyme, potentially leading to drug-drug interactions.

See Also

• Phase I metabolism
• Phase II metabolism
• Drug metabolism
• Gilbert's syndrome

References

Glucuronidation Resources
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