Glucuronic acid
Glucuronic acid is a uronic acid that plays significant roles in the metabolism of microorganisms, plants, and animals. It is derived from glucose, a type of sugar, and is a key component in the detoxification process of harmful substances in the body.
Structure and Properties[edit | edit source]
Glucuronic acid is a carboxylic acid that consists of six carbon atoms. It is a monosaccharide sugar acid derived from glucose, with the sixth carbon atom oxidized to a carboxylic acid.
Biological Role[edit | edit source]
In humans and other animals, glucuronic acid is involved in the detoxification of substances by the liver. It is a part of the glucuronidation process, where it combines with toxic substances to make them more water-soluble, allowing for easier excretion through the urine or bile.
Medical Significance[edit | edit source]
Glucuronic acid is crucial in the metabolism of certain drugs, including nonsteroidal anti-inflammatory drugs (NSAIDs), benzodiazepines, and morphine. It is also involved in the metabolism of bilirubin, a waste product of red blood cell breakdown, and its deficiency can lead to conditions like Gilbert's syndrome.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
