Uncinate fasciculus
Uncinate Fasciculus
The Uncinate Fasciculus is a prominent white matter tract in the human brain that connects parts of the limbic system such as the hippocampus and amygdala in the temporal lobe with frontal cortex areas.
Etymology[edit | edit source]
The term "uncinate" comes from the Latin word "uncinatus", which means "hooked", while "fasciculus" is derived from the Latin word "fascis", meaning "bundle". This is in reference to the hook-like shape of this bundle of nerve fibers.
Anatomy[edit | edit source]
The uncinate fasciculus is a curved bundle of fibers (or 'fasciculus') in the brain. It connects regions of the frontal lobe, specifically the orbitofrontal cortex, with the anterior parts of the temporal lobe, including the amygdala and hippocampus.
Function[edit | edit source]
The uncinate fasciculus plays a crucial role in the neural network underlying emotional processing and regulation, social behavior, and cognitive functions such as memory and attention. It is also involved in the integration of information related to olfaction and emotion.
Clinical Significance[edit | edit source]
Alterations in the uncinate fasciculus have been associated with a variety of neurological and psychiatric disorders, including Alzheimer's disease, schizophrenia, bipolar disorder, and major depressive disorder.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
